| Chemical Specifications | |
|---|---|
| Product Name | Survodutide (BI 456906 – Dual GLP-1/GCG Agonist) |
| CAS Number | 1913490-48-2 |
| Molecular Formula | C214H337N57O69S |
| Molecular Weight | 4836.4 g/mol (4.84 kDa) |
| Purity (HPLC) | ≥ 99.0% (Clinical/Research Grade) |
| Target Receptors | Dual Agonist (GLP-1R & GCGR) |
| Appearance | White Lyophilized Powder |
| Storage | Store at -20°C or 2°C to 8°C (Protect from light) |
What is Survodutide (BI 456906)?
Survodutide (10mg x 10 Vials Kit) is the apex of modern metabolic engineering, acting as the ultimate “Dual-Engine Force.” Unlike first-generation weight-loss peptides that solely target the GLP-1 receptor to suppress appetite, Survodutide is a revolutionary GLP-1 and Glucagon (GCG) Receptor Dual Agonist. By activating the Glucagon receptor, it forces the body to actively increase Energy Expenditure (basal metabolic rate) and rapidly clear out ectopic fat, specifically from the liver. It is the definitive research tool for shattering stubborn metabolic plateaus, shifting subjects from “passive starvation” into a state of “active hyper-metabolism.”
Key Features & Metabolic Breakthroughs
Active Energy Expenditure
The Glucagon (GCG) agonist component directly stimulates thermogenesis and lipid oxidation. Instead of just eating less, the body is chemically instructed to actively burn more calories at rest, defying metabolic slowdown.
Hepatic Fat Clearance
Demonstrates unprecedented efficacy in aggressively clearing visceral fat and lipid accumulation within the liver (NASH/MASH models), restoring optimal hepatic insulin sensitivity and systemic health.
Plateau Shattering Power
When subjects adapt to extreme caloric restriction on GLP-1s alone, their metabolism crashes, causing a plateau. Survodutide bypasses this by keeping the metabolic furnace burning hot despite lower food intake.
Potent Appetite Suppression
Retains a highly powerful GLP-1 receptor affinity. It seamlessly controls cravings, eliminates “food noise,” and delays gastric emptying, providing the foundational caloric deficit needed for extreme fat loss.
Dual-Receptor Synergy
The perfect biochemical balancing act. GLP-1 controls the insulin response and intake, while Glucagon commands fat mobilization and output. Together, they create an inescapable environment for fat oxidation.
Clinical-Grade 10mg Yield
Provided in a massive 10mg per vial format (100mg total kit), ensuring researchers have the precise, high-purity dosing volume required for extended, dose-escalating metabolic studies.
How It Works: The “Dual-Engine” Metabolic Override
The fatal flaw of traditional weight-loss research is the body’s evolutionary survival mechanism. When you introduce a standard GLP-1 agonist, the subject eats significantly less. The body interprets this severe caloric deficit as starvation and responds by drastically lowering its Basal Metabolic Rate (BMR) to conserve energy. This is why extreme weight loss eventually stalls into a brutal, unbreakable plateau. You are eating less, but burning even less.
Survodutide completely overrides this survival mechanism by deploying the “Glucagon Hack.” Glucagon is the hormone counter-regulatory to insulin; its natural job is to signal the body that it needs energy, prompting it to break down stored glycogen and adipose tissue (fat). By simultaneously agonizing both the GLP-1 and Glucagon (GCG) receptors, Survodutide forces the body into a paradoxical state of hyper-efficiency.
First, the GLP-1 engine shuts down the appetite, creating a massive caloric deficit. Second, instead of letting the metabolism crash, the Glucagon engine revs up, forcing the mitochondria to increase Energy Expenditure and aggressively oxidize stored fat—particularly the toxic visceral fat surrounding the liver. This “Dual-Engine” effect means the subject experiences the appetite suppression of a GLP-1, but the roaring, active metabolism of someone performing intense cardiovascular exercise. It is the ultimate pharmacological tool for actively incinerating adipose tissue without losing metabolic momentum.
🧪 What’s In The Kit
- Active Compound: Survodutide (BI 456906)
- Classification: GLP-1 & GCGR Dual Agonist
- Format: 10-Vial Research Kit
- Net Contents: 10mg per vial (100mg Total)
- Purity: Clinical/Research Grade (≥99%)
👩🔬 Who Uses It
- Advanced Metabolic & Obesity Researchers
- Hepatology Labs (NASH/MASH Studies)
- Extreme Body Composition Specialists
- Researchers Investigating Metabolic Adaptation
🔗 Best Paired With
- Bacteriostatic Water (For sterile reconstitution)
- Precision Insulin Syringes
- Refrigerated Storage (2°C – 8°C)
- Consistent Protein Intake Protocols